Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane

@article{Belitsky2004GenotoxicityAC,
  title={Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane},
  author={Gennady A Belitsky and T. A. Lytcheva and I. A. Khitrovo and R. D. Safaev and V. S. Zhurkov and I. F. Vyskubenko and L. P. Sytshova and O G Salamatova and E. G. Feldt and V. V. Khudoley and Igor V. Mizgirev and E. M. Khovanova and E. G. Ugnivenko and T. B. Tanirbergenov and K. I. Malinovskaya and Yu. A. Revazova and Faina I. Ingel and V. Bratslavsky and Alexey Terentyev and A. A. Shapiro and G. M. Williams},
  journal={Cell Biology and Toxicology},
  year={2004},
  volume={10},
  pages={265-279}
}
The activities of 1,2-dibromopropane (DBP) and 1,1,3-tribromopropane (TBP) were studied in seven genotoxicity assays, (i) SOS-induction inE. coli, (ii) DNA repair in primary rat hepatocyte culture, (iii) theSalmonella/microsome assay, (iv) a host-mediated assay usingSalmonella, (v) the somatic mutation and recombination assay inDrosophila melanogaster, (vi) HGPRT-mutagenesis assay in ARL 18 cells, and (vii) micronucleus formation assay in mouse polychromatophylic erythrocytes (PCE), forestomach… 

Developmental toxicity and genotoxicity studies of 1,1,1,3,3,3-hexachloropropane (HCC-230fa) in rats.

The results of these studies suggest that HCC-230fa affects rapidly dividing cells and may have long-term consequences for occupational exposures.

Developmental Toxicity and Genotoxicity Studies of

Evidence of maternal and developmental toxicity was observed at 25 ppm and was noted as significant, compound-related reductions in mean maternal body weight, weight change, and food consumption and significant fetal effects also were observed.

Evaluation of Organ Specificity of Mutagenic Effects of Cyclophosphamide in Mice by Micronucleus Test

  • L. P. Sycheva
  • Biology, Medicine
    Bulletin of Experimental Biology and Medicine
  • 2004
In vivo cytogenetic effects of cyclophosphamide was simultaneously evaluated in 7 mouse organs and can be used for evaluation of organ specificity of mutagens and for prediction of the carcinogenic effects of chemical compounds.

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