Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes.

@article{Jackman1994GenotoxicSC,
  title={Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes.},
  author={Joany Jackman and Isaac Alamo and Albert J. Fornace},
  journal={Cancer research},
  year={1994},
  volume={54 21},
  pages={5656-62}
}
The growth arrest and DNA damage-inducible (gadd) genes represent a group of five stress-inducible genes that are coordinately regulated at the transcriptional level. Posttranscriptional regulation of gadd153, gadd45, gadd34, gadd33, and gadd7 was studied after exposure to DNA-damaging agents or other growth arrest treatments in hamster cells. Relative transcript levels were measured following treatment with the transcriptional inhibitor actinomycin D. After exposure to methylmethane sulfonate… CONTINUE READING

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