Genotoxic potential of medroxyprogesterone acetate in cultured human peripheral blood lymphocytes.

@article{Siddique2006GenotoxicPO,
  title={Genotoxic potential of medroxyprogesterone acetate in cultured human peripheral blood lymphocytes.},
  author={Yasir Hasan Siddique and Gulshan Ara and Tanveer S Beg and Mohammad Afzal},
  journal={Life sciences},
  year={2006},
  volume={80 3},
  pages={212-8}
}
Medroxyprogesterone acetate was studied at three different concentrations (1, 5 and 10 microM), for its genotoxic effects in human peripheral blood lymphocyte culture using chromosomal aberrations and sister chromatid exchanges as parameters. Duplicate peripheral blood cultures were treated with three different concentrations (1, 5 and 10 microM) of medroxyprogesterone acetate. The study was carried out both in the absence as well as in the presence of metabolic activation (S9 mix) with and… CONTINUE READING

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