Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.

@article{Arumugam2009GenotoxicPO,
  title={Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.},
  author={Paritha I. Arumugam and Tomoyasu Higashimoto and Fabrizia Urbinati and Ute Modlich and Shawna Nestheide and Ping Xia and Catherine Fox and Andrea Corsinotti and Christopher Baum and Punam Malik},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2009},
  volume={17 11},
  pages={1929-37}
}
Insertional mutagenesis by long terminal repeat (LTR) enhancers in gamma-retrovirus-based vectors (GVs) in clinical trials has prompted deeper investigations into vector genotoxicity. Experimentally, self-inactivating (SIN) lentivirus vectors (LVs) and GV containing internal promoters/enhancers show reduced genotoxicity, although strong ubiquitously-active enhancers dysregulate genes independent of vector type/design. Herein, we explored the genotoxicity of beta-globin (BG) locus control region… CONTINUE READING