Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis

@article{Yue2003GenotoxicMO,
  title={Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis},
  author={Wei Yue and Richard J Santen and J-P Wang and Yan Li and Michael F Verderame and Wayne P. Bocchinfuso and Ks Korach and Prabu D Devanesan and Rosa Todorovic and E G Rogan and Ercole L Cavalieri},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2003},
  volume={86},
  pages={477-486}
}
  • W. Yue, R. Santen, +8 authors E. Cavalieri
  • Published 1 September 2003
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
Long term exposure to estradiol increases the risk of breast cancer in a variety of animal species, as well as in women. The mechanisms responsible for this effect have not been firmly established. The prevailing theory proposes that estrogens increase the rate of cell proliferation by stimulating estrogen receptor-mediated transcription and thereby the number of errors occurring during DNA replication. An alternative hypothesis proposes that estradiol can be metabolized to quinone derivatives… Expand
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