Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts.

@article{Burcham1998GenotoxicLP,
  title={Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts.},
  author={Philip C. Burcham},
  journal={Mutagenesis},
  year={1998},
  volume={13 3},
  pages={287-305}
}
The peroxidation of polyunsaturated lipids generates a range of substances that possess DNA damaging potential. This includes lipid hydroperoxides and various species that contain unpaired electrons, such as the alkoxyl and peroxyl radicals. In addition, a range of genotoxic carbonyl-containing compounds are formed, such as malondialdehyde, various 4-hydroxy-2-alkenals such as 4-hydroxynonenal and a number of 2-alkenals. It has previously been assumed that the antioxidants and electrophile… CONTINUE READING

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