Genotoxic effects of malathion: an organophosphorus insecticide, using three mammalian bioassays in vivo.

@article{Giri2002GenotoxicEO,
  title={Genotoxic effects of malathion: an organophosphorus insecticide, using three mammalian bioassays in vivo.},
  author={Sarbani Giri and Surya Bali Prasad and Anirudha Giri and Gouri Dutt Sharma},
  journal={Mutation research},
  year={2002},
  volume={514 1-2},
  pages={223-31}
}
The genotoxic effects of malathion was evaluated using chromosome aberration, sister chromatid exchange (SCE) and sperm abnormality assays in mice. All the three acute doses (2.5, 5 and 10mg/kg) of malathion tested in the present study, induced significant dose-dependent increase in the frequency of chromosome aberrations and sperm abnormalities, but did not affect the total sperm count. The highest acute dose induced a >12-fold increase in the frequency of chromosome aberrations, two-fold… CONTINUE READING