Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.

  title={Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.},
  author={Nan Mei and Jiaxiang Hu and Mona I. Churchwell and Lei Guo and Martha M. Moore and Daniel R. Doerge and Tao Chen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={46 2},
In addition to occupational exposures to acrylamide (AA), concerns about AA health risks for the general population have been recently raised due to the finding of AA in food. In this study, we evaluated the genotoxicity of AA and its metabolite glycidamide (GA) in L5178Y/Tk(+/-) mouse lymphoma cells. The cells were treated with 2-18 mM of AA or 0.125-4 mM of GA for 4 h without metabolic activation. The DNA adducts, mutant frequencies and the types of mutations for the treated cells were… CONTINUE READING


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