• DOI:10.1016/j.taap.2015.03.016
Corpus ID: 11059163

Genotoxic effect of ethacrynic acid and impact of antioxidants.

@article{Ward2015GenotoxicEO,
  title={Genotoxic effect of ethacrynic acid and impact of antioxidants.},
  author={William M Ward and Jared D. Hoffman and G. Loo},
  journal={Toxicology and applied pharmacology},
  year={2015},
  volume={286 1},
  pages={
          17-26
        }
}

William M Ward, Jared D. Hoffman, G. Loo

Published 2015

Chemistry, Medicine

Toxicology and applied pharmacology

It is known that ethacrynic acid (EA) decreases the intracellular levels of glutathione. Whether the anticipated oxidative stress affects the structural integrity of DNA is unknown. Therefore, DNA damage was assessed in EA-treated HCT116 cells, and the impact of several antioxidants was also determined. EA caused both concentration-dependent and time-dependent DNA damage that eventually resulted in cell death. Unexpectedly, the DNA damage caused by EA was intensified by either ascorbic acid or… CONTINUE READING

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