Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation

@article{Inomata2009GenotoxicSA,
  title={Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation},
  author={Ken Inomata and Takahiro Aoto and Nguyễn Thị Thanh B{\`i}nh and Natsuko Okamoto and Shintaro Tanimura and Tomohiko Wakayama and Shoichi Iseki and Eiji Hara and Takuji Masunaga and Hiroshi Shimizu and Emi K. Nishimura},
  journal={Cell},
  year={2009},
  volume={137},
  pages={1088-1099}
}
Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes. Hair graying, a typical sign of aging in mammals, is caused by the incomplete maintenance of melanocyte stem cells (MSCs) with age. Here, we report that irreparable DNA damage, as caused by ionizing radiation, abrogates renewal of MSCs in mice. Surprisingly, the DNA-damage response triggers MSC differentiation into mature melanocytes in the niche, rather than… Expand
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