Genotoxic Agents Promote the Nuclear Accumulation of Annexin A2: Role of Annexin A2 in Mitigating DNA Damage

@inproceedings{Madureira2012GenotoxicAP,
  title={Genotoxic Agents Promote the Nuclear Accumulation of Annexin A2: Role of Annexin A2 in Mitigating DNA Damage},
  author={Patr{\'i}cia A Madureira and Richard O. Hill and Patrick Wing Kwong Lee and David. M. Waisman},
  booktitle={PloS one},
  year={2012}
}
Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma membrane, however a small population has been found in the nucleus, suggesting a nuclear function for the protein. Annexin A2 possesses a nuclear export sequence (NES) and inhibition of the NES is sufficient to cause nuclear accumulation. Here we show that… CONTINUE READING