Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance.

@article{Calin2006GenomicsOC,
  title={Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance.},
  author={George A. Calin and Carlo M. Croce},
  journal={Seminars in oncology},
  year={2006},
  volume={33 2},
  pages={167-73}
}
Chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults in the Western world, is characterized by predominantly nondividing malignant CD5+ B cells overexpressing the anti-apoptotic Bcl2 protein. Significant familial aggregation with largely unknown mode of inheritance has been demonstrated. Until recently little else was known regarding the events leading to CLL initiation and progression. New findings support the view that CLL is a genetic disease where the main alterations… CONTINUE READING
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