Genomics for disease treatment and prevention.

@article{Bloss2011GenomicsFD,
  title={Genomics for disease treatment and prevention.},
  author={Cinnamon S. Bloss and Dilip V. Jeste and Nicholas J. Schork},
  journal={The Psychiatric clinics of North America},
  year={2011},
  volume={34 1},
  pages={
          147-66
        }
}

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References

SHOWING 1-10 OF 89 REFERENCES

Genomic and personalized medicine: foundations and applications.

  • G. GinsburgH. Willard
  • Medicine
    Translational research : the journal of laboratory and clinical medicine
  • 2009

From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions.

Se sequencing of the entire human genome, the mapping of common haplotypes of single-nucleotide polymorphisms (SNPs), and cost-effective genotyping technologies leading to genome-wide association studies - have combined convincingly in the past several years to demonstrate the requirements needed to separate true associations from the plethora of false positives.

The HapMap and genome-wide association studies in diagnosis and therapy.

The development and application of the HapMap to genome-wide association (GWA) studies; present and future technologies for GWA research; current major efforts in GWA studies; successes and limitations of the GWA approach in identifying polymorphisms related to complex diseases; data release and privacy polices; and sources of ongoing authoritative information on this rapidly evolving field are examined.

DNA, drugs and chariots: on a decade of pharmacogenomics at the US FDA.

Four major areas that need to be addressed collectively to assure that pharmacogenomics continues to mature over the next 10 years into a science that is essential to the practice of medicine are presented.

Future health applications of genomics: priorities for communication, behavioral, and social sciences research.

Prediction of individual genetic risk of complex disease.

The role of companion diagnostics in the development and use of mutation-targeted cancer therapies

Development of companion diagnostic tests for this identification of patients most likely to benefit from therapies based on agents that specifically target the products of the genes that are mutated in cancer cells is proceeding.

A HapMap harvest of insights into the genetics of common disease.

HapMap-based discoveries have shed new light on the impact of evolutionary pressures on the human genome, suggesting multiple loci important for adapting to disease-causing pathogens and new environments.

The implications of gene–environment interactions in depression: will cause inform cure?

  • R. Uher
  • Psychology, Biology
    Molecular Psychiatry
  • 2008
A model of depression is proposed that incorporates the interacting genetic and environmental factors over the life course and provides an explanatory framework for the heterogeneous aetiology of depression.

Finding the missing heritability of complex diseases

Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture.
...