Genomics-driven oncology: framework for an emerging paradigm.

@article{Garraway2013GenomicsdrivenOF,
  title={Genomics-driven oncology: framework for an emerging paradigm.},
  author={Levi A. Garraway},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2013},
  volume={31 15},
  pages={
          1806-14
        }
}
A majority of cancers are driven by genomic alterations that dysregulate key oncogenic pathways influencing cell growth and survival. However, the ability to harness tumor genetic information for its full clinical potential has only recently become manifest. Over the past several years, the convergence of discovery, technology, and therapeutic development has created an unparalleled opportunity to test the hypothesis that systematic knowledge of genomic information from individual tumors can… CONTINUE READING
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