Genomics and evolution of protein phosphatases

@article{Chen2017GenomicsAE,
  title={Genomics and evolution of protein phosphatases},
  author={Mark Jinan Chen and Jack E. Dixon and Gerard Manning},
  journal={Science Signaling},
  year={2017},
  volume={10}
}
Protein phosphatases are the essential opposite to protein kinases; together, these enzymes regulate all protein phosphorylation and most cellular processes. [] Key Method We traced the origin and diversity of phosphatases by building protein phosphatomes for eight other eukaryotes, from the protist Dictyostelium to the sea urchin. We classified protein phosphatases from all nine species into a hierarchy of 10 protein folds, 21 families, and 178 subfamilies. We found that >80% of the 101 human subfamilies…
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