Genomics: the next step to elucidate the etiology of calcific aortic valve stenosis.

  title={Genomics: the next step to elucidate the etiology of calcific aortic valve stenosis.},
  author={Yohan Boss{\'e} and Patrick Mathieu and Philippe Pibarot},
  journal={Journal of the American College of Cardiology},
  volume={51 14},
With the current shift toward an older population, calcific aortic valve stenosis (AVS) is likely to become a major societal and economic burden. For many years, AVS was regarded as a degenerative and nonmodifiable process. However, molecular studies unanimously demonstrated that AVS is an actively regulated disorder with several potential therapeutic targets. Many factors are predicted to cause AVS, and an important genetic predisposition is anticipated. In this review, we describe candidate… CONTINUE READING
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