Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum.

@article{Li2008GenomicsTA,
  title={Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum.},
  author={B. Li and R. Predel and S. Neupert and F. Hauser and Yoshiaki Tanaka and G. Cazzamali and M. Williamson and Y. Arakane and P. Verleyen and L. Schoofs and J. Schachtner and C. Grimmelikhuijzen and Yoonseong Park},
  journal={Genome research},
  year={2008},
  volume={18 1},
  pages={
          113-22
        }
}
Neuropeptides and protein hormones are ancient molecules that mediate cell-to-cell communication. The whole genome sequence from the red flour beetle Tribolium castaneum, along with those from other insect species, provides an opportunity to study the evolution of the genes encoding neuropeptide and protein hormones. We identified 41 of these genes in the Tribolium genome by using a combination of bioinformatic and peptidomic approaches. These genes encode >80 mature neuropeptides and protein… Expand
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A genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum
TLDR
The survey of 340 million years of insect neurohormone GPCR evolution shows that neuropeptide/receptor couples can easily duplicate or disappear during insect evolution and shows that Drosophila is not a good representative of all insects, because several of the hormonal systems that the authors now find in Tribolium do not exist in Dosophila. Expand
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