Genomic views of STAT function in CD4+ T helper cell differentiation

  title={Genomic views of STAT function in CD4+ T helper cell differentiation},
  author={John J O'Shea and Riitta Lahesmaa and Golnaz Vahedi and Arian D J Laurence and Yuka Kanno},
  journal={Nature Reviews Immunology},
Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (TH) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The… CONTINUE READING
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