Genomic views of STAT function in CD4+ T helper cell differentiation

@article{OShea2011GenomicVO,
  title={Genomic views of STAT function in CD4+ T helper cell differentiation},
  author={John J O'Shea and Riitta Lahesmaa and Golnaz Vahedi and Arian D J Laurence and Yuka Kanno},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={239-250}
}
Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (TH) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The… CONTINUE READING
92 Extracted Citations
146 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 92 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 146 references

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

  • H Ji
  • Nature 467,
  • 2010

Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation

  • L Wei
  • Immunity 32,
  • 2010

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R–IL12RB2 regions associated with Behcet’s disease

  • Remmers, F E.
  • Nature Genet
  • 2010

Similar Papers

Loading similar papers…