Genomic subtyping and therapeutic targeting of acute erythroleukemia

  title={Genomic subtyping and therapeutic targeting of acute erythroleukemia},
  author={Ilaria Iacobucci and Ji Long Wen and Manja Meggendorfer and John Kim Choi and Lei Shi and Stanley B Pounds and Catherine L. Carmichael and Katherine E Masih and Sarah Margaret Morris and R. Coleman Lindsley and Laura J Janke and Thomas B Alexander and Guangchun Song and Chunxu Qu and Yongjin Li and Debbie Payne-Turner and Daisuke Tomizawa and Nobutaka Kiyokawa and Marcus Valentine and Virginia Valentine and Giuseppe Basso and Franco Locatelli and Eric J Enemark and Shirley Kow-Yin Kham and Allen Eng Juh Yeoh and Xiaotu Ma and Xin Zhou and Edgar Sioson and Michael C Rusch and Rhonda E Ries and Elliot Stieglitz and Stephen P Hunger and Andrew H Wei and Luen Bik To and Ian David Lewis and Richard J. D'Andrea and Benjamin T Kile and Anna L. Brown and Hamish S. Scott and Christopher N Hahn and Paula Marlton and Deqing Pei and Cheng Cheng and Mignon L Loh and Benjamin L. Ebert and Soheil Meshinchi and Torsten Haferlach and Charles G Mullighan},
  journal={Nature Genetics},
Acute erythroid leukemia (AEL) is a high-risk leukemia of poorly understood genetic basis, with controversy regarding diagnosis in the spectrum of myelodysplasia and myeloid leukemia. We compared genomic features of 159 childhood and adult AEL cases with non-AEL myeloid disorders and defined five age-related subgroups with distinct transcriptional profiles: adult, TP53 mutated; NPM1 mutated; KMT2A mutated/rearranged; adult, DDX41 mutated; and pediatric, NUP98 rearranged. Genomic features… CONTINUE READING


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