Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2

  title={Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2},
  author={E. G. Ward and Konstantina Grosios and A. F. Markham and P.F. Jones},
  journal={Cytogenetic and Genome Research},
  pages={147 - 154}
The family of human angiopoietins comprises factors with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to the endothelial cell-specific receptor, Tie2. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. In this study the genomic structures of all three human angiopoietins were characterised by direct sequencing of human genomic DNA… 

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