Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes.

@article{Hosokawa2007GenomicSA,
  title={Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes.},
  author={Masakiyo Hosokawa and Tomomi Furihata and Yumiko Yaginuma and Naoko Yamamoto and Nao Koyano and Ayako Fujii and Yuko Nagahara and Testuo Satoh and Kan Chiba},
  journal={Drug metabolism reviews},
  year={2007},
  volume={39 1},
  pages={1-15}
}
The mammalian carboxylesterases (CESs) comprise a multigene family which gene products play important roles in biotransformation of ester- or amide-type prodrugs. Since expression level of CESs may affect the pharmacokinetic behavior of prodrugs in vivo, it is important to understand the transcriptional regulation mechanism of the CES genes. However, little is known about the gene structure and transcriptional regulation of the mammalian CES genes. In the present study, to investigate the… CONTINUE READING

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