Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI.

@article{Luo2001GenomicSA,
  title={Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI.},
  author={Robert Z. Luo and Hui-ming Peng and Faye Xu and Jin-ku Bao and Y. -J. Pang and Rashmi Pershad and Jean-Pierre Issa and Warren S-L Liao and Robert C. Bast and Yonghao Yu},
  journal={Biochimica et biophysica acta},
  year={2001},
  volume={1519 3},
  pages={216-22}
}
We have recently identified a maternally imprinted tumor suppressor gene, ARHI (aplysia ras homolog I), the expression of which is lost in ovarian and breast cancers. We have now characterized the genomic structure of the gene including its promoter and the methylation status of its upstream CpG islands. The ARHI gene spans approximately 8 kb containing two exons and one intron. Exon 1 contains 81 non-translated nucleotides, connected to exon 2 with a 3.2-kb intron. The entire protein-coding… CONTINUE READING

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