Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer.

@article{Oba2001GenomicSA,
  title={Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer.},
  author={Satoshi. Oba and You jie Wang and Jian ping Song and Zhong you Li and Kazuyasu Kobayashi and Shoichiro Tsugane and Gerson Shigeaki Hamada and Masamitsu Tanaka and Haruhiko Sugimura},
  journal={Cancer letters},
  year={2001},
  volume={164 1},
  pages={97-104}
}
EphB2, a member of the Eph receptor protein-tyrosine kinase family, is overexpressed in several human gastrointestinal tumors. Furthermore, the EphB2 gene is localized at 1p35-p36.1, a frequently deleted region in colon and other cancers. So, despite its overexpression in some kind of tumors, we decided to study the possibility of involvement in the EphB2 gene (EPHB2) mutation in colon cancers, because some of the well known tumor suppressor genes (e.g. p53) is overexpressed (really accumulated… CONTINUE READING

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