Genomic structure and functional control of the Dlx3-7 bigene cluster.

@article{Sumiyama2002GenomicSA,
  title={Genomic structure and functional control of the Dlx3-7 bigene cluster.},
  author={Kenta Sumiyama and Steven Q Irvine and David W. Stock and Kenneth M. Weiss and Kazuhiko Kawasaki and Nobuyoshi Shimizu and Cooduvalli S. Shashikant and Webb Miller and F. H. Ruddle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 2},
  pages={
          780-5
        }
}
The Dlx genes are involved in early vertebrate morphogenesis, notably of the head. The six Dlx genes of mammals are arranged in three convergently transcribed bigene clusters. In this study, we examine the regulation of the Dlx3-7 cluster of the mouse. We obtained and sequenced human and mouse P1 clones covering the entire Dlx3-7 cluster. Comparative analysis of the human and mouse sequences revealed several highly conserved noncoding regions within 30 kb of the Dlx3-7-coding regions. These… CONTINUE READING
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