Genomic structure and amino acid sequence domains of the human La autoantigen.

  title={Genomic structure and amino acid sequence domains of the human La autoantigen.},
  author={Jasemine Choy Chambers and D J Kenan and Bradley J. Martin and Jack D. Keene},
  journal={The Journal of biological chemistry},
  volume={263 34},
La is an autoimmune RNA-binding protein of 47 kDa that plays a role in the transcription of RNA polymerase III. Both genomic and complementary DNAs were isolated that encompass the coding sequence of the human La molecule. The genomic clones encompass 11 exons and a putative G/C-rich promoter upstream of the mRNA start site. The cDNA sequence encodes a protein of 408 amino acids and can be divided into two structural domains based upon amino acid content and protease sensitivity. An unusually… CONTINUE READING


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