Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene.

@article{Chen2000GenomicSE,
  title={Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene.},
  author={Y M Chen and Leslie Y Y Chen and F. H. Wong and Chin Mei Lee and Tien J Chang and Teresa L. Yang-Feng},
  journal={Genomics},
  year={2000},
  volume={66 1},
  pages={43-7}
}
The glycine N-methyltransferase (GNMT) gene encodes a protein that not only acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine, but also participates in the detoxification pathway in liver cells. Previously, we reported that the expression level of GNMT was diminished in human hepatocellular carcinoma. In this study, the human GNMT gene was cloned and characterized. It contains six exons and spans about 10 kb. Instead of a TATA box, it has a… CONTINUE READING