Genomic structural variations lead to dysregulation of important coding and non‐coding RNA species in dilated cardiomyopathy

@article{Haas2018GenomicSV,
  title={Genomic structural variations lead to dysregulation of important coding and non‐coding RNA species in dilated cardiomyopathy},
  author={Jan Haas and Stefan Mester and Alan Lai and Karen S. Frese and Farbod Sedaghat-Hamedani and Elham Kayvanpour and Tobias Rausch and Rouven Nietsch and Jes Niels Boeckel and Avisha Carstensen and Mirko V{\"o}lkers and Carsten Dietrich and Dietmar Pils and Ali Amr and Daniel Holzer and diana martins bordalo and Daniel Oehler and Tanja M Weis and Derliz Mereles and Sebastian J. Buss and Eva Riechert and Emil Wirsz and Maximilian Wuerstle and Jan O. Korbel and Andreas Keller and Hugo A. Katus and Andreas E. Posch and Benjamin Meder},
  journal={EMBO Molecular Medicine},
  year={2018},
  volume={10},
  pages={107 - 120}
}
The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non‐coding RNAs. Besides this dynamic regulation, a large part of phenotypic variability of eukaryotes is expressed through changes in gene transcription caused by genetic variation. In this study, we evaluate genome‐wide structural genomic variants (SVs) and their association with gene expression in the human heart. We detected 3,898 individual SVs affecting… 
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