Genomic spectra of biliary tract cancer

  title={Genomic spectra of biliary tract cancer},
  author={H. Nakamura and Y. Arai and Y. Totoki and Tomoki Shirota and A. Elzawahry and M. Kato and Natsuko Hama and F. Hosoda and Tomoko Urushidate and S. Ohashi and N. Hiraoka and Hidenori Ojima and K. Shimada and T. Okusaka and T. Kosuge and S. Miyagawa and T. Shibata},
  journal={Nature Genetics},
  • H. Nakamura, Y. Arai, +14 authors T. Shibata
  • Published 2015
  • Biology, Medicine
  • Nature Genetics
  • The incidence of biliary tract cancer (BTC), including intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinoma and gallbladder cancer, has increased globally; however, no effective targeted molecular therapies have been approved at the present time. Here we molecularly characterized 260 BTCs and uncovered spectra of genomic alterations that included new potential therapeutic targets. Gradient spectra of mutational signatures with a higher burden of the APOBEC-associated mutation signature… CONTINUE READING
    400 Citations

    Paper Mentions

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    ConditionsBenign Hepatobiliary Disease, Biliary Tract Cancer, Cholangiocarcinoma, (+5 more)
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