Genomic spectra of biliary tract cancer

@article{Nakamura2015GenomicSO,
  title={Genomic spectra of biliary tract cancer},
  author={Hiromi Nakamura and Yasuhito Arai and Yasushi Totoki and Tomoki Shirota and Asmaa Elzawahry and Mamoru Kato and Natsuko Hama and F. Hosoda and Tomoko Urushidate and Shoko Ohashi and Nobuyoshi Hiraoka and Hidenori Ojima and Kazuaki Shimada and Takuji Okusaka and Tomoo Kosuge and Shinichi Miyagawa and Tatsuhiro Shibata},
  journal={Nature Genetics},
  year={2015},
  volume={47},
  pages={1003-1010}
}
The incidence of biliary tract cancer (BTC), including intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinoma and gallbladder cancer, has increased globally; however, no effective targeted molecular therapies have been approved at the present time. Here we molecularly characterized 260 BTCs and uncovered spectra of genomic alterations that included new potential therapeutic targets. Gradient spectra of mutational signatures with a higher burden of the APOBEC-associated mutation signature… CONTINUE READING
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