Genomic simple repetitive DNAs are targets for differential binding of nuclear proteins.

@article{Epplen1996GenomicSR,
  title={Genomic simple repetitive DNAs are targets for differential binding of nuclear proteins.},
  author={J{\"o}rg T. Epplen and Andreas Kyas and W. M{\"a}ueler},
  journal={FEBS letters},
  year={1996},
  volume={389 1},
  pages={92-5}
}
The biological meaning of abundant simple repetitive DNA sequences in eukaryote genomes is obscure. Therefore, (GAA)n, (GT)n, and composite (GT)n(GA)m, blocks were characterized for protein binding in the repeat and flanking sequences of cloned genomic DNA fragments. In gel mobility shift and competition assays the binding of nuclear proteins to the repeats was specific (including some flanking single copy sequences). DNase footprinting revealed the target sequences within and adjacent to the… CONTINUE READING

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