Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

  title={Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus},
  author={William C. Nierman and Arnab Pain and Michael James Anderson and Jennifer R. Wortman and H. Stanley Kim and Javier Arroyo and Matthew Berriman and Keietsu Abe and David Brian Archer and Clara Bermejo and Joan W Bennett and Paul Bowyer and Dan Chen and Matthew David Collins and Richard Coulsen and R. A. H. Davies and Paul S. Dyer and Mark L. Farman and Nadia Fedorova and Natalie D. Fedorova and Tamara V. Feldblyum and Reinhard Fischer and Nigel Fosker and Audrey Fraser and Jos{\'e} L. Garc{\'i}a and Mar{\'i}a Jos{\'e} Garc{\'i}a and Arlette Goble and Gustavo Henrique Goldman and Katsuya Gomi and Sam Griffith-Jones and Ryan Gwilliam and Brian J. Haas and Hubertus Haas and David E Harris and Hiroyuki Horiuchi and Jiaqi Huang and Sean J. Humphray and Javier Jim{\'e}nez and Nancy P. Keller and Hoda M. Khouri and Katsuhiko Kitamoto and Tetsuo Kobayashi and Sven Konzack and Resham D. Kulkarni and Toshitaka Kumagai and Anne Lafton and Jean Paul Latg{\'e} and Weixi Li and Angela Lord and Charles Lu and William H. Majoros and Gregory S. May and Bruce L. Miller and Yasmin A. Mohamoud and Maria Molina and Michel Monod and Isabelle Mouyna and Stephanie Mulligan and Lee D Murphy and Susan O'neil and Ian T. Paulsen and Miguel A. Pe{\~n}alva and Mihaela Pertea and Claire Emile Price and Beth L. Pritchard and Michael A. Quail and Ester H Rabbinowitsch and Neil Rawlins and Marie-Ad{\`e}le Rajandream and Utz Reichard and Hubert Renauld and G. D. Robson and Santiago Rodrı́guez de C{\'o}rdoba and Jos{\'e} M Rodr{\'i}guez-Pe{\~n}a and Catherine M. Ronning and Simon R. Rutter and Steven L. Salzberg and Miguel del Nogal S{\'a}nchez and Juan Carlos Sanchez-Ferrero and David L. Saunders and Kathy Seeger and Rob Squares and Steven Squares and Michio Takeuchi and Fredj Tekaia and Geoffrey Turner and C. V{\'a}zquez de Aldana and Janice F. Weidman and Owen White and John Robert Woodward and Jae-Hyuk Yu and Claire M. Fraser and James E. Galagan and Kiyoshi Asai and Masayuki Machida and Neil Hall and Bart Barrell and David W. Denning},
Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other… 
Genomics of Aspergillus fumigatus.
Study of Aspergillus fumigatus pathogenicity and identification of putative virulence genes
A new expression microarray covering the entire genome of A. fumigatus was designed to analyze its transcriptome at the first steps of germination and along a disseminated infection, and genes involved in carbohydrate and secondary metabolism, and even those encoding unclassified and hypothetical proteins stood out as indispensable pathways for extending the infection.
Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus
We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri
Proteome of conidial surface associated proteins of Aspergillus fumigatus reflecting potential vaccine candidates and allergens.
Proteome analysis is now a powerful tool to confirm expression of hypothetical proteins and, thereby, to identify additional vaccine candidates and possible new allergens of this important fungal pathogen.
Extensive sequence divergence of non-coding regions between Aspergillus fumigatus, a major fungal pathogen of humans, and its relatives
This work identified 418 genes, including 25 genes known to modulate A. fumigatus virulence, in a subset of orthologous genes with highly conserved non-coding regions across the phylogeny, which shows that closely related Aspergillus species that vary greatly in their pathogenicity exhibit extensive non-Coding sequence variation.
The aspergilli provide a good example of what can be gained from genome sequences and highlights some of the problems.
Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection.
This study defines the pan-genome of A. fumigatus using a collection of 300 globally sampled genomes and leverages the power of genome-wide association studies to identify genomic variation associated with clinical isolates and triazole resistance as well as characterize genetic variation in known virulence factors.
Genetics and Genomics of aspergillus Fla VUS
The ability of the fimgus to grow at relatively high temperatures of the fungus contributes to its pathogenicity in humans and other warm blooded animals.


Aspergillus fumigatus and Aspergillosis
  • J. Latgé
  • Biology, Medicine
    Clinical Microbiology Reviews
  • 1999
This review focuses on the biology of A. fumigatus, one of the most ubiquitous of the airborne saprophytic fungi, and the diseases it causes, and discusses discussions of genomic and molecular characterization of the organism.
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution, and a comparative study with Aspergillus fumigatus and As pergillus oryzae, used in the production of sake, miso and soy sauce, provides new insight into eukaryotic genome evolution and gene regulation.
Genome sequencing and analysis of Aspergillus oryzae
Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation.
LaeA, a Regulator of Secondary Metabolism in Aspergillus spp
A novel Aspergillus nuclear protein, LaeA, is presented here as a global regulator of secondary metabolism in this genus, and strains show little difference in spore production compared to the wild type, indicating that the primary role of laeA is to regulate metabolic gene clusters.
Fungal antigens as a source of sensitization and respiratory disease in Scottish maltworkers
Mycological and serological studies were carried out as part of a survey of respiratory disease in Scottish maltworkers. 70% of stained sputum smears from 574 workers showed the presence of higher
Structural flexibility in the Burkholderia mallei genome.
Variation in simple sequence repeats in key genes can provide a mechanism for generating antigenic variation that may account for the mammalian host's inability to mount a durable adaptive immune response to a B. mallei infection.
Microbial Methylation of Metalloids: Arsenic, Antimony, and Bismuth
As described in this review, many microorganisms (bacteria, fungi, and yeasts) and animals are now known to biomethylate arsenic, forming both volatile and nonvolatile compounds, including methylarsines and trimethylstibine.
Host-Pathogen Interactions: Redefining the Basic Concepts of Virulence and Pathogenicity
Historical concepts of microbial pathogenicity and virulence are reviewed, new definitions are proposed, and a classification system for microbial pathogens based on their ability to cause damage as a function of the host’s immune response is suggested.
The diagnosis of actinomycosis is not easy and demands special processing of the specimens, and combination of surgical and pharmaceutical treatments is necessary for the therapy of act inomycotic patients.