• DOI:10.1038/nature04332
• Corpus ID: 4338031

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

@article{Nierman2005GenomicSO,
  title={Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus},
  author={William C. Nierman and Arnab Pain and Michael James Anderson and Jennifer R. Wortman and H. Stanley Kim and Javier Arroyo and Matthew Berriman and Keietsu Abe and David Brian Archer and Clara Bermejo and Joan W Bennett and Paul Bowyer and Dan Chen and Matthew David Collins and Richard Coulsen and R. A. H. Davies and Paul S. Dyer and Mark L. Farman and Nadia Fedorova and Natalie D. Fedorova and Tamara V. Feldblyum and Reinhard Fischer and Nigel Fosker and Audrey Fraser and Jos{\'e} L. Garc{\'i}a and Mar{\'i}a Jos{\'e} Garc{\'i}a and Arlette Goble and Gustavo Henrique Goldman and Katsuya Gomi and Sam Griffith-Jones and Ryan Gwilliam and Brian J. Haas and Hubertus Haas and David E Harris and Hiroyuki Horiuchi and Jiaqi Huang and Sean J. Humphray and Javier Jim{\'e}nez and Nancy P. Keller and Hoda M. Khouri and Katsuhiko Kitamoto and Tetsuo Kobayashi and Sven Konzack and Resham D. Kulkarni and Toshitaka Kumagai and Anne Lafton and Jean Paul Latg{\'e} and Weixi Li and Angela Lord and Charles Lu and William H. Majoros and Gregory S. May and Bruce L. Miller and Yasmin A. Mohamoud and Maria Molina and Michel Monod and Isabelle Mouyna and Stephanie Mulligan and Lee D Murphy and Susan O'neil and Ian T. Paulsen and Miguel A. Pe{\~n}alva and Mihaela Pertea and Claire Emile Price and Beth L. Pritchard and Michael A. Quail and Ester H Rabbinowitsch and Neil Rawlins and Marie-Ad{\`e}le Rajandream and Utz Reichard and Hubert Renauld and G. D. Robson and Santiago Rodrı́guez de C{\'o}rdoba and Jos{\'e} M Rodr{\'i}guez-Pe{\~n}a and Catherine M. Ronning and Simon R. Rutter and Steven L. Salzberg and Miguel del Nogal S{\'a}nchez and Juan Carlos Sanchez-Ferrero and David L. Saunders and Kathy Seeger and Rob Squares and Steven Squares and Michio Takeuchi and Fredj Tekaia and Geoffrey Turner and C. V{\'a}zquez de Aldana and Janice F. Weidman and Owen White and John Robert Woodward and Jae-Hyuk Yu and Claire M. Fraser and James E. Galagan and Kiyoshi Asai and Masayuki Machida and Neil Hall and Bart Barrell and David W. Denning},
  journal={Nature},
  year={2005},
  volume={438},
  pages={1151-1156}
}

• W. Nierman, A. Pain, +95 authors D. Denning
• Published 22 December 2005
• Biology
• Nature

Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus.