Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

  title={Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi},
  author={C. Fraser and S. Casjens and W. Huang and G. Sutton and Rebecca Clayton and R. Lathigra and O. White and K. A. Ketchum and R. Dodson and E. Hickey and M. Gwinn and B. Dougherty and Jean-Francois Tomb and R. Fleischmann and D. Richardson and J. Peterson and A. Kerlavage and J. Quackenbush and S. Salzberg and Mark Hanson and R. V. Vugt and N. Palmer and M. Adams and J. Gocayne and Janice Weidman and T. Utterback and Larry Watthey and Lisa McDonald and P. Artiach and C. Bowman and Stacey Garland and C. Fujii and M. Cotton and K. Horst and Kevin Roberts and B. Hatch and H. Smith and J. Venter},
  • C. Fraser, S. Casjens, +35 authors J. Venter
  • Published 1997
  • Biology, Medicine
  • Nature
  • The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular plasmids with a combined size of more than 533,000 base pairs. [...] Key Result Of 430 genes on 11 plasmids, most have no known biological function; 39% of plasmid genes are paralogues that form 47 gene families. The biological significance of the multiple plasmid-encoded genes is not clear, although they may be involved in antigenic…Expand Abstract
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