Genomic search for prostate cancer predisposition loci in Utah pedigrees.

  title={Genomic search for prostate cancer predisposition loci in Utah pedigrees.},
  author={Nicola J. Camp and James Michael Farnham and Lisa Anne Cannon Albright},
  journal={The Prostate},
  volume={65 4},
BACKGROUND We report a genome linkage scan in extended Utah pedigrees, utilizing a pedigree-splitting approach to reduce intra-familial heterogeneity. METHODS Fifty-nine pedigrees with at least four Prostate cancer (PrCa) cases and no more than two meioses separating PrCa cases were analyzed using the CIDR genomic search STRP marker set. Parametric linkage analyses using dominant and recessive models were performed on four datasets resulting from a pedigree splitting algorithm. In addition… CONTINUE READING

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