Genomic screening and replication using the same data set in family-based association testing

@article{Steen2005GenomicSA,
  title={Genomic screening and replication using the same data set in family-based association testing},
  author={Kristel Van Steen and Matthew B Mcqueen and Alan Herbert and Benjamin A. Raby and Helen Lyon and Dawn L. DeMeo and Amy E. Murphy and Jessica A Su and Soma Datta and Carsten Rosenow and Michael F. Christman and Edwin K. Silverman and Nan M. Laird and Scott T. Weiss and Christoph Lange},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={683-691}
}
The Human Genome Project and its spin-offs are making it increasingly feasible to determine the genetic basis of complex traits using genome-wide association studies. The statistical challenge of analyzing such studies stems from the severe multiple-comparison problem resulting from the analysis of thousands of SNPs. Our methodology for genome-wide family-based association studies, using single SNPs or haplotypes, can identify associations that achieve genome-wide significance. In relation to… CONTINUE READING
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