Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile.

@article{Lercher2004GenomicRI,
  title={Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile.},
  author={Martin J. Lercher and Jean-Vincent Chamary and Laurence D. Hurst},
  journal={Genome research},
  year={2004},
  volume={14 6},
  pages={1002-13}
}
In mammalian genomes, linked genes show similar rates of evolution, both at fourfold degenerate synonymous sites (K4) and at nonsynonymous sites (KA). Although it has been suggested that the local similarity in the synonymous substitution rate is an artifact caused by the inclusion of disparately evolving gene pairs, we demonstrate here that this is not the case: after removal of disparately evolving genes, both (1) linked genes and (2) introns from the same gene have more similar silent… CONTINUE READING