Genomic profiling of isolated circulating tumor cells from metastatic breast cancer patients.


Molecular characterization of circulating tumor cells (CTC) from blood is technically challenging because cells are rare and difficult to isolate. We developed a novel approach to isolate CTCs from blood via immunomagnetic enrichment followed by fluorescence-activated cell sorting (IE-FACS). Isolated CTCs were subjected to genome-wide copy number analysis… (More)
DOI: 10.1158/0008-5472.CAN-11-3017