Genomic profiling of B-progenitor acute lymphoblastic leukemia.

  title={Genomic profiling of B-progenitor acute lymphoblastic leukemia.},
  author={Charles G Mullighan},
  journal={Best practice & research. Clinical haematology},
  volume={24 4},
Childhood acute lymphoblastic leukemia (ALL) is comprised of multiple subtypes defined by recurring chromosomal alterations that are important events in leukemogenesis and are widely used in diagnosis and risk stratification, yet fail to fully explain the biology of this disease. In the last 5 years, genome-wide profiling of gene expression, structural DNA alterations and sequence variations has yielded important insights into the nature of submicroscopic genetic alterations that define novel… CONTINUE READING
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