Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.

Abstract

Background Gliomas are diverse neoplasms with multiple molecular subtypes. How tumor-initiating mutations relate to molecular subtypes as these tumors evolve during malignant progression remains unclear. Methods We used genetically engineered mouse models, histopathology, genetic lineage tracing, expression profiling, and copy number analyses to examine… (More)
DOI: 10.1093/neuonc/nox050

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