Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification.

@article{Ahn2014GenomicPO,
  title={Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification.},
  author={Sung-Min Ahn and Se Jin Jang and Ju Hyun Shim and Deokhoon Kim and Seung-Mo Hong and Chang Ohk Sung and Daehyun Baek and Farhan Ul Haq and Adnan Ahmad Ansari and Sun Young Lee and S. M. Chun and Seongmin Choi and Hyun-jeung Choi and Jongkyu Kim and Sukjun Kim and Shin Won Hwang and Young-Joo Lee and Jong-Eun Lee and Wang-rim Jung and Hye Yoon Jang and Eunho Yang and Wing-Kin Sung and Nikki P.Y. Lee and Mao Mao and Charles Lee and Jessica Zucman-Rossi and Eunsil Yu and Han Chu Lee and G K Kong},
  journal={Hepatology},
  year={2014},
  volume={60 6},
  pages={1972-82}
}
UNLABELLED Hepatic resection is the most curative treatment option for early-stage hepatocellular carcinoma, but is associated with a high recurrence rate, which exceeds 50% at 5 years after surgery. Understanding the genetic basis of hepatocellular carcinoma at surgically curable stages may enable the identification of new molecular biomarkers that accurately identify patients in need of additional early therapeutic interventions. Whole exome sequencing and copy number analysis was performed… CONTINUE READING
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