Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform.

@article{Olofsson1996GenomicOO,
  title={Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform.},
  author={Birgitta Olofsson and Katri Pajusola and Gabriel von Euler and Dmitri Chilov and Kari Alitalo and Ulf Eriksson},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 32},
  pages={19310-7}
}
A second isoform and the genomic structures of mouse and human vascular endothelial growth factor B are described. Both genes consist of seven coding exons and span about 4 kilobases of DNA. The two identified isoforms of vascular endothelial growth factor B are generated by alternative splicing where different splice acceptor sites in exon 6 introduce a frameshift and a partial use of different but overlapping reading frames. Consequently, the COOH-terminal domains in the two isoforms show no… CONTINUE READING
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