Genomic organization of the mammalian MHC.

  title={Genomic organization of the mammalian MHC.},
  author={Attila Kum{\'a}novics and Toyoyuki Takada and Kirsten Fischer Lindahl},
  journal={Annual review of immunology},
The Human Genome Project transformed the quest of more than 50 years to understand the major histocompatibility complex (Mhc). The sequence of the Mhc from human and mouse, together with a large amount of sequence and mapping information from several other species, allows us to draw general conclusions about the organization and origin of this crucial part of the immune system. The Mhc is a mosaic of stretches formed by conserved and nonconserved genes. Surprisingly, of the approximately 3.6-Mb… CONTINUE READING

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