Genomic organization of the human LAG-3/CD4 locus

@article{Bruniquel1997GenomicOO,
  title={Genomic organization of the human LAG-3/CD4 locus},
  author={Denis Bruniquel and Nathalie Borie and Frederic Triebel},
  journal={Immunogenetics},
  year={1997},
  volume={47},
  pages={96-98}
}
Efficient T-cell activation leading to clonal expansion and differentiation requires a signal derived from the T-cell receptor (TCR)/CD3 complex and a second signal mediated by CD28. In the absence of costimulatory signals provided by antigen-presenting cells, T-cell unresponsiveness is induced. Major histocompatibility complex (MHC) ligands such as CD4, CD8, and lymphocyte activation gene-3 molecules (LAG-3) (Triebel et al. 1990; Baixeras et al. 1992) generally play a role in modulating these… Expand
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TLDR
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TLDR
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