Genomic organization of the adrenoleukodystrophy gene.

  title={Genomic organization of the adrenoleukodystrophy gene.},
  author={Claude Olivier Sarde and Jean Mosser and Petra Kioschis and Christine Kretz and Serge Vicaire and Patrick R Aubourg and Annemarie Poustka and J. L. Mandel},
  volume={22 1},
Adrenoleukodystrophy (ALD), the most frequent peroxisomal disorder, is a severe neurodegenerative disease associated with an impairment of very long chain fatty acids beta-oxidation. We have recently identified by positional cloning the gene responsible for ALD, located in Xq28. It encodes a new member of the "ABC" superfamily of membrane-associated transporters that shows, in particular, significant homology to the 70-kDa peroxisomal membrane protein (PMP70). We report here a detailed… CONTINUE READING


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