Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135.

@article{Kojima2001GenomicOO,
  title={Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135.},
  author={Toshio Kojima and Yasuhiro Yoshikawa and Shuji Takada and Manabu Sato and Takahiro Nakamura and Nami Takahashi and Neal G. Copeland and Debra J. Gilbert and Nancy A. Jenkins and Naoki Mori},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={284 4},
  pages={1039-47}
}
The Shc gene family is an emerging family, containing at least three members designated Shc/ShcA, Sck/Sli/ShcB, N-Shc/Rai/ShcC in mammals. In this study, we determined the genomic organization of the mouse Shc family. Coding regions of ShcA, B, and C each comprised 12 exons, spanned approximately 6, 20, and 65 kb, and located on chromosome 3, 10, and 13, respectively. Based on this genome analysis, we determined the full-length structure of mouse Sck/ShcB as a 68-kD protein. We found that the… CONTINUE READING

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