Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.

@article{Buisine1998GenomicOO,
  title={Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.},
  author={Marie-Pierre Buisine and Jean-Luc Desseyn and Nicole Porchet and Pierre Degand and Anne Laine and J. P. Aubert},
  journal={The Biochemical journal},
  year={1998},
  volume={332 ( Pt 3)},
  pages={729-38}
}
The human mucin gene MUC5AC is mapped clustered with MUC2, MUC5B and MUC6 on chromosome 11p15.5. We report here the isolation and characterization of a genomic cosmid clone, designated ELO9, spanning the 3'-region of MUC5AC and the 5'-region of MUC5B, allowing us to conclude that MUC5AC and MUC5B have the same transcriptional orientation. We determined the genomic organization and the entire sequence of the 3'-region of MUC5AC. The comparative molecular analysis of MUC5AC and MUC5B points to a… CONTINUE READING

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