Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer

@article{Krmer2000GenomicOO,
  title={Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer},
  author={Franziska Kr{\"a}mer and Karen F. White and Manfred Kubbies and Karen Swisshelm and Bernhard H. F. Weber},
  journal={Human Genetics},
  year={2000},
  volume={107},
  pages={249-256}
}
Human claudin-1 is an integral protein component of tight junctions, a structure controlling cell-to-cell adhesion and, consequently, regulating paracellular and transcellular transport of solutes across human epithelia and endothelia. Recently, a claudin-1 (CLDN1) cDNA has been isolated from human mammary epithelial cells (HMECs). CLDN1 expression in HMECs, in contrast to low or undetectable levels of expression in a number of breast tumors and breast cancer cell lines, points to CLDN1 as a… CONTINUE READING
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