Genomic organization and transcriptional units at the myotonic dystrophy locus.

@article{Shaw1993GenomicOA,
  title={Genomic organization and transcriptional units at the myotonic dystrophy locus.},
  author={Duncan J. Shaw and Mila E. McCurrach and Shelley A. Rundle and Helen G. Harley and S R Crow and Regina Sohn and J-P. Thirion and Marion G. Hamshere and Alan J. Buckler and P S Harper},
  journal={Genomics},
  year={1993},
  volume={18 3},
  pages={673-9}
}
The genomic structure and apparently complete coding sequence of the myotonic dystrophy protein kinase gene have been determined. The gene contains 15 exons distributed over about 13 kb of genomic DNA. It codes for a protein of 624 amino acids with an N-terminal domain highly homologous to cAMP-dependent serine-threonine protein kinases, an intermediate domain with a high alpha-helical content and weak similarity to various filamentous proteins, and a hydrophobic C-terminal segment. Located in… CONTINUE READING