Genomic organization and promoter analysis of the Dnmt3b gene.

  title={Genomic organization and promoter analysis of the Dnmt3b gene.},
  author={Chisaki Ishida and Kiyoe Ura and Akiko Hirao and Hiroyuki Sasaki and Atsushi Toyoda and Yoshiyuki Sakaki and Hitoshi Niwa and En Li and Yasufumi Kaneda},
The Dnmt3b gene encodes a de novo DNA methyltransferase that is essential for normal mouse development. It is highly expressed in early embryos and embryonic stem (ES) cells but downregulated in most adult somatic tissues. To gain insight into the regulation of Dnmt3b, we have isolated a mouse genomic bacterial artificial chromosome clone that contains the Dnmt3b gene. Complete sequence analysis of the clone demonstrated that Dnmt3b consists of at least 24 exons and spans 38 kilobases. S1… CONTINUE READING


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