Genomic organization, sequence and polymorphism of the human chromosome 4-specific alpha-satellite DNA.

@article{Mashkova1994GenomicOS,
  title={Genomic organization, sequence and polymorphism of the human chromosome 4-specific alpha-satellite DNA.},
  author={T. D. Mashkova and Tat'yana A Akopian and L Y Romanova and S. P. Mitkevich and Yuri B. Yurov and L. L. Kisselev and Ivan A. Alexandrov},
  journal={Gene},
  year={1994},
  volume={140 2},
  pages={211-7}
}
Two alpha-satellite fragments specific for human chromosome 4 have been cloned and characterized. Under stringent annealing conditions, they hybridized in situ only to the pericentromeric region of chromosome 4, but under non-stringent conditions they hybridized to all chromosomes containing the sequences of alpha-satellite suprachromosomal family 2 (viz., chromosomes 2, 4, 8, 9, 13, 14, 15, 18, 20, 21 and 22). Southern blot analysis reveals the 3.2-kb higher-order repeated unit which exists in… CONTINUE READING