Genomic mechanisms of transformation from chronic obstructive pulmonary disease to lung cancer.

@article{Wang2017GenomicMO,
  title={Genomic mechanisms of transformation from chronic obstructive pulmonary disease to lung cancer.},
  author={Diane Catherine Wang and Lin Fang Shi and Zhenhua Zhu and Danyan Gao and Yong Zhang},
  journal={Seminars in cancer biology},
  year={2017},
  volume={42},
  pages={
          52-59
        }
}
Genetic variations in COPD and lung cancer may be one of the molecular mechanisms responsible for COPD-lung cancer transformation. The present review highlights main genetic variations co-existed in COPD and lung cancer and integrates the varied genes into four molecular mechanisms, e.g. activated cell proliferation pathway, tumor suppressor and DNA repair gene dysfunction, chronic inflammatory microenvironment, and impaired immune response, by which COPD epithelial cells may be transformed… CONTINUE READING
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Chronic obstructive pulmonary disease and lung cancer: a lethal association.

  • American journal of respiratory and critical care medicine
  • 2011
VIEW 11 EXCERPTS
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