Genomic mapping of cAMP receptor protein (CRPMt) in Mycobacterium tuberculosis: relation to transcriptional start sites and the role of CRPMt as a transcription factor

@inproceedings{Kahramanoglou2014GenomicMO,
  title={Genomic mapping of cAMP receptor protein (CRPMt) in Mycobacterium tuberculosis: relation to transcriptional start sites and the role of CRPMt as a transcription factor},
  author={Christina Kahramanoglou and Teresa Romero Cort{\'e}s and Nishad Matange and Debbie M. Hunt and Sandhya S Visweswariah and Douglas Brownlee Young and Roger S Buxton},
  booktitle={Nucleic acids research},
  year={2014}
}
Chromatin immunoprecipitation identified 191 binding sites of Mycobacterium tuberculosis cAMP receptor protein (CRP(Mt)) at endogenous expression levels using a specific α-CRP(Mt) antibody. Under these native conditions an equal distribution between intragenic and intergenic locations was observed. CRP(Mt) binding overlapped a palindromic consensus sequence. Analysis by RNA sequencing revealed widespread changes in transcriptional profile in a mutant strain lacking CRP(Mt) during exponential… CONTINUE READING
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